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Revumenib Tablets (Revuforj)
The U.S. Food and Drug Administration has approved the first menin inhibitor, revumenib, for the treatment of relapsing or refractory acute leukemia with a lysine methyltransferase 2A gene (also known as the mixed lineage leukemia gene) translocation in adults and pediatric patients.
Oseltamivir for Adults Hospitalized with Influenza: Earlier Is Better
A multicenter observational study on adults hospitalized with influenza found that initiation of oseltamivir on the day of admission reduced the risk of disease progression, including pulmonary and extra-pulmonary organ failure and death.
Wildfire Smoke Exposure Is a Risk Factor for Dementia
In this large, open cohort study based on electronic health record data from 2009 to 2019 of dementia-free people older than 60 years of age, exposure to wildfire smoke was shown to result in an increased incidence of dementia later in life.
A New Treatment for Heart Failure with Preserved Ejection Fraction
A recent randomized, placebo-controlled trial of the long-acting glucagon-like peptide-1 receptor agonist tirzepatide in patients with heart failure with preserved left ventricular ejection fraction who have obesity, diabetes, and one other weight-related comorbidity has shown that tirzepatide reduces both the symptoms of heart failure as well as the incidence of worsening heart failure events.
Drugs and Toxins that Produce Delayed Toxicities
Drug overdose is a common chief complaint in the emergency department. Overdose of certain medications or ingestions of toxins should prompt the emergency physician to carefully deliberate on the appropriate next steps and disposition. Furthermore, delayed toxicity may be under-recognized, and delayed management can lead to life-threatening complications, such as arrhythmias and seizures. Managing the poisoned patient can be challenging because clinical effects often are difficult to predict in circumstances that produce toxicity.
Physicians Need Better Information, Training in Miscarriage Management
Many women — maybe even most pregnant patients with miscarriage complications — are not offered a full range of options of the best evidence-based miscarriage management.
Social Issues Are a Big Challenge in Adolescent Contraceptive Access
A decade of failed improvements has shown that money needs to be focused less on a game changer and more on using strategies that work, including those that address social norms.
Contraceptive Implant Can Lead to Weight Gain, But It Is Not Medically Concerning
Clinicians providing contraceptive counseling should be aware of recent research showing that young people can experience weight gain when using hormonal implants, when compared with young people using some other types of contraceptives.
California’s Efforts to Reduce Maternal Mortality and Morbidity Show Promise
When California was faced with unacceptably high rates of maternal deaths and disparities among minority patients, the state formed a collaborative to tackle this problem and find solutions.
How Are Maternal Deaths Counted and Investigated?
Determining a city, state, or country’s maternal mortality rate is challenging and can be a controversial process. It depends on the time frame measured, whether maternal deaths are considered only if there are biomedical causes, or when there are factors related to pregnancy, such as suicides and homicides that would have not occurred if the person had not had a pregnancy.